有过敏反应的非哮喘性鼻息肉患者表现出更高的上皮基质金属蛋白酶阳性率。
Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.
作者信息
Shin Hyun-Woo, Han Doo Hee, Lim Yune Sung, Kim Hye Jung, Kim Dong-Young, Lee Chul Hee, Min Yang-Gi, Rhee Chae-Seo
机构信息
Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
出版信息
Otolaryngol Head Neck Surg. 2009 Oct;141(4):442-7. doi: 10.1016/j.otohns.2009.07.011.
OBJECTIVE
To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis.
STUDY DESIGN
A case-control study.
SETTING
A tertiary referral center.
SUBJECTS AND METHODS
The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosin staining were also performed and those expression levels were compared.
RESULTS
Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group.
CONCLUSION
The presence of AR may enhance the expression of MMP-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis.
目的
确定变应性鼻炎（AR）对鼻息肉中基质金属蛋白酶（MMP）-9、MMP-2和金属蛋白酶组织抑制剂-1（TIMP-1）表达的影响。
研究设计
病例对照研究。
研究地点
三级转诊中心。
研究对象与方法
对20例接受鼻内镜鼻窦手术的AR患者和20例非变应性患者的鼻息肉组织（NP）和上颌窦黏膜（MM）样本中MMP-9、MMP-2和TIMP-1的表达进行研究。还进行了三色染色、过碘酸-希夫染色和苏木精-伊红染色，并比较了这些表达水平。
结果
嗜酸性粒细胞浸润在NP中比在MM中更明显，尤其是在有AR的情况下。在AR患者的NP中，观察到MMP-9、MMP-2和TIMP-1的表达比对照组更显著增加。然而，在MM中，AR患者和对照组之间没有显著差异。
结论
AR的存在可能增强鼻息肉中与气道重塑相关的MMP-9、MMP-2和TIMP-1的表达。
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