高效微波辅助不对称二硫醚合成。
Efficient microwave-assisted synthesis of unsymmetrical disulfides.
机构信息
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany.
出版信息
J Org Chem. 2010 Mar 5;75(5):1811-3. doi: 10.1021/jo902695a.
PMID:20121046
Abstract
An efficient synthesis of unsymmetrical disulfides exemplified for cysteines and penicillamines is described. The use of dimethyl sulfoxide mediated oxidation accelerated by microwave irradiation afforded various unsymmetrical disulfides in one step and in high yields.
摘要
描述了一种高效合成不对称二硫醚的方法，以半胱氨酸和青霉素胺为例。使用二甲亚砜介导的氧化，通过微波辐射加速，一步法以高产率得到了各种不对称二硫醚。
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