Anal Chem. 2010 Mar 1;82(5):1598-600. doi: 10.1021/ac9027388.
Over 60% of current pharmaceutical drugs have origins in natural products. To expand on current methods allowing one to characterize natural products directly from bacterial culture, herein we describe the use of desorption electrospray ionization (DESI) imaging mass spectrometry in monitoring the exchange of secondary metabolites between Bacillus subtilis and Streptomyces coelicolor using a simple imprinting technique.
超过 60%的现有药物都源自天然产物。为了扩展当前可直接从细菌培养物中对天然产物进行特征分析的方法，本研究采用解吸电喷雾电离（DESI）成像质谱技术，结合简单的印迹技术，监测枯草芽孢杆菌和变铅青链霉菌之间次生代谢物的交换。
