浆果鞣花单宁可能不足以预防啮齿动物食道肿瘤。
Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus.
机构信息
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA.
出版信息
J Agric Food Chem. 2010 Apr 14;58(7):3992-5. doi: 10.1021/jf9030635.
Abstract
Biodirected fractionation is used to identify the active inhibitory constituents in berries for esophageal cancer in rats. The present study was undertaken to determine if ellagitannins contribute to the chemopreventive activity of an alcohol/water-insoluble (residue) fraction of berries. Rats consumed diets containing residue fractions of three berry types, that is, black raspberries (BRBs), strawberries (STRWs), and blueberries (BBs), that differ in their content of ellagitannins in the order BRB > STRW > BB. Animals were fed residue diets beginning 2 weeks before treatment with the esophageal carcinogen N-nitrosomethylbenzylamine (NMBA) and throughout the 30-week bioassay. Residue fractions from all three berry types were about equally effective in reducing NMBA tumorigenesis in the rat esophagus irrespective of their ellagitannin content (0.01-0.62 g/kg of diet). These results suggest that the ellagitannins may not be responsible for the chemopreventive effects of the alcohol/water-insoluble fraction of berries.
摘要
生物导向分离用于鉴定对大鼠食管癌具有抑制活性的浆果中有效成分。本研究旨在确定鞣花单宁是否对浆果醇/水不溶（残渣）部分的化学预防活性有贡献。大鼠摄入含有三种浆果残渣部分的饮食，即黑莓（BRB）、草莓（STRW）和蓝莓（BB），其鞣花单宁含量依次为 BRB>STRW>BB。动物在接受食管致癌剂 N-亚硝基甲基苄胺（NMBA）治疗前 2 周和整个 30 周生物测定期间开始摄入残渣饮食。无论其鞣花单宁含量如何（0.01-0.62g/kg 饮食），三种浆果残渣部分对降低 NMBA 诱导的大鼠食管肿瘤形成均具有同等的效果。这些结果表明，鞣花单宁可能不是浆果醇/水不溶部分的化学预防作用的原因。
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