Towers Craig V, Rumney Pamela J, Ghamsary Mark G
Long Beach Memorial Women's Hospital, Long Beach, CA, USA.
J Matern Fetal Neonatal Med. 2010 Oct;23(10):1091-6. doi: 10.3109/14767050903580359.
To evaluate the absolute CD4+, CD8+, and lymphocyte cell counts and percentages from the first trimester through 6-12 weeks post-delivery in normal human immunodeficiency virus (HIV)-negative pregnant patients.
A longitudinal laboratory analysis was performed during pregnancy that involved 51 HIV-negative subjects with blood analysis obtained in all trimesters, at delivery, and 6-12 weeks post-delivery. Twenty-five HIV-negative non-pregnant controls were also evaluated. Blood was analysed for absolute CD4+, CD8+, and lymphocyte cell counts and percentages. Means, standard deviations, trends, and differences were examined.
The mean white blood cell (WBC) count is elevated above the non-pregnant state and this parameter increases through the pregnancy up to and including parturition. The mean absolute lymphocyte cell count, lymphocyte percentage, and absolute CD4+ cell count are significantly lower during pregnancy and the progression through pregnancy appears U-shaped. The mean absolute CD8+ cell count is not significantly different. The CD4+ and CD8+ percentages are higher during pregnancy and this elevation persists into the 6-12 week post-delivery time period. A 3-digit drop in CD4+ percentage is common during pregnancy between blood draws; whereas, a 30% decrease or more in absolute CD4+ cell count is rare.
By longitudinal analysis, pregnancy appears to significantly elevate the mean values of the WBC count, CD4+ percentage, and CD8+ percentage, but significantly decreases the absolute lymphocyte count, lymphocyte percentage, and absolute CD4+ cell count when compared to non-pregnant controls. The mean absolute CD8+ cell count appears to be unaffected.
评估正常人类免疫缺陷病毒（HIV）阴性的孕妇从孕早期到产后6 - 12周的绝对CD4⁺、CD8⁺淋巴细胞计数及百分比。
对51名HIV阴性孕妇在孕期进行纵向实验室分析，包括在孕各期、分娩时及产后6 - 12周进行血液分析。还评估了25名HIV阴性的非孕对照者。分析血液中的绝对CD4⁺、CD8⁺淋巴细胞计数及百分比。检查均值、标准差、趋势和差异。
平均白细胞（WBC）计数高于非孕状态，且该参数在孕期直至分娩时均升高。平均绝对淋巴细胞计数、淋巴细胞百分比和绝对CD4⁺细胞计数在孕期显著降低，且孕期变化呈U形。平均绝对CD8⁺细胞计数无显著差异。CD4⁺和CD8⁺百分比在孕期较高，且这种升高持续到产后6 - 12周。孕期采血期间CD4⁺百分比常见下降3位数；而绝对CD4⁺细胞计数下降30%或更多则少见。
通过纵向分析，与非孕对照者相比，妊娠似乎显著提高了白细胞计数、CD4⁺百分比和CD8⁺百分比的平均值，但显著降低了绝对淋巴细胞计数、淋巴细胞百分比和绝对CD4⁺细胞计数。平均绝对CD8⁺细胞计数似乎未受影响。
