癌症蛋白质组表达数据库：日本蛋白质组学基因组医学数据库。

Cancer proteome-expression database: Genome Medicine Database of Japan Proteomics.

机构信息

Proteome Bioinformatics Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

出版信息

Expert Rev Proteomics. 2010 Feb;7(1):21-7. doi: 10.1586/epr.09.87.

DOI:10.1586/epr.09.87

PMID:20121473

Abstract

The use of proteome-expression databases may facilitate cancer research. Proteome-expression data derived from a sufficient number of clinical cases may help establish the molecular background of malignant tumors. Recently, we published a proteome expression database, the Genome Medicine Database of Japan (GeMDBJ) Proteomics. The GeMDBJ Proteomics includes the proteome data of surgically resected tissues and tissue-cultured cells of various malignancies, as well as the corresponding biological and clinicopathological data. The proteome data in GeMDBJ Proteomics include expression data produced using 2D PAGE with the immobilized pH gradient gel and DIGE technology, and the protein identification data by liquid chromatography tandem mass spectrometry. GeMDBJ Proteomics can be freely accessed online without registration.

摘要

蛋白质组表达数据库的使用可能有助于癌症研究。从足够数量的临床病例中获得的蛋白质组表达数据可能有助于确定恶性肿瘤的分子背景。最近，我们发布了一个蛋白质组表达数据库，即日本基因组医学数据库（GeMDBJ）蛋白质组学。该数据库包含各种恶性肿瘤手术切除组织和组织培养细胞的蛋白质组数据，以及相应的生物学和临床病理数据。GeMDBJ 蛋白质组学中的蛋白质组数据包括使用固定 pH 梯度凝胶的 2D PAGE 和 DIGE 技术产生的表达数据，以及通过液相色谱串联质谱获得的蛋白质鉴定数据。GeMDBJ 蛋白质组学可以免费在线访问，无需注册。