Department of Clinical and Molecular Virology, University of Edinburgh, Summerhall, United Kingdom.
Clin Infect Dis. 2010 Mar 1;50(5):699-706. doi: 10.1086/650456.
Infectious mononucleosis (IM) is common among university students. We undertook to analyze the clinical features and sequelae of the disease in a cohort of students at Edinburgh University.
Consecutive IM case patients were recruited from 2000 through 2002 at the University Health Service after diagnosis of IM.
IM resulted in marked reductions in student study time, physical exercise, and non-exercise-related social activities, and sustained increases in reported number of hours of sleep. The disease profile differed between the sexes, with significantly more females reporting fatigue, which was more likely to be prolonged (P = .003) and to lead to loss of study time (P = .013). Female case patients were more likely to discontinue their studies following IM (16% vs 0%; P = .056). Within the typically elevated lymphocyte counts in IM, we identified an elevated gammadelta T cell component that may contribute to the disease pathogenesis.
IM results in substantial morbidity among university students, reported as more profound in females, and affecting academic studies, physical exercise, and social activities. Immunization to prevent IM and strategies to reduce post-IM disability would be beneficial in this population.
传染性单核细胞增多症（IM）在大学生中很常见。我们分析了爱丁堡大学一群学生的疾病临床特征和后遗症。
2000 年至 2002 年，在大学健康服务处诊断为 IM 后，连续招募 IM 病例患者。
IM 导致学生学习时间、体育锻炼和非体育相关社交活动明显减少，睡眠时间增加。疾病特征在性别之间存在差异，女性报告疲劳的比例明显更高（P =.003），且更可能持续时间延长（P =.003）并导致学习时间减少（P =.013）。女性病例患者在 IM 后更有可能辍学（16%比 0%；P =.056）。在 IM 中典型升高的淋巴细胞计数中，我们发现了升高的 gammadelta T 细胞成分，这可能有助于疾病发病机制。
IM 在大学生中导致相当大的发病率，女性报告的发病率更高，影响学业、体育锻炼和社交活动。预防 IM 的免疫接种和减少 IM 后残疾的策略将对这一人群有益。
