Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Institute for Clinical and Translational Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
J Am Coll Health. 2022 Jan;70(1):22-25. doi: 10.1080/07448481.2020.1726927. Epub 2020 Feb 26.
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which disproportionately affects university students. This population has the potential to benefit from a prophylactic EBV vaccine trial. Our objectives were to determine EBV infection status and associated demographic/lifestyle factors among first year undergraduate university students at the beginning and end of first year.
EBV infection status was assessed by testing for circulating IgG class antibodies against EBV viral capsid antigen.
Of 198 starting students; 56.1% were positive for EBV antibodies with a higher rate in women (64.8%) than male (41.1%); p = 0.002. A history of deep kissing was associated with a higher rate of EBV antibody positivity. On follow-up 8 months later at the end of freshman year, 22.4% had acquired EBV antibodies for a primary infection incidence of 33.6/100 person years.
These findings indicate that our first year undergraduate population contains sufficient EBV-naïve subjects for a prophylactic vaccine trial.
爱泼斯坦-巴尔病毒（EBV）是传染性单核细胞增多症的病因，该病在大学生中发病率较高。该人群有可能从预防性 EBV 疫苗试验中受益。我们的目的是在大学一年级开始和结束时，确定一年级本科生的 EBV 感染状况及相关的人口统计学/生活方式因素。
通过检测针对 EBV 病毒衣壳抗原的循环 IgG 类抗体来评估 EBV 感染状况。
在 198 名起始学生中；56.1%的人 EBV 抗体阳性，女性（64.8%）的阳性率高于男性（41.1%）；p=0.002。深吻史与 EBV 抗体阳性率较高相关。8 个月后的随访期末，即大学一年级结束时，有 22.4%的人获得了 EBV 抗体，原发性感染发病率为 33.6/100 人年。
这些发现表明，我们的一年级本科生群体中有足够数量的 EBV 初发者可用于预防性疫苗试验。
