Comprehensive Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Am Geriatr Soc. 2010 Jan;58(1):76-82. doi: 10.1111/j.1532-5415.2009.02620.x.
To evaluate objective physical performance measures as predictors of survival and subsequent disability in older patients with cancer.
Longitudinal cohort study.
Health, Aging and Body Composition (Health ABC) Study.
Four hundred twenty-nine individuals diagnosed with cancer during the first 6 years of follow-up of the Health ABC Study.
The associations between precancer measures of physical performance (20-m usual gait speed, 400-m long-distance corridor walk (LDCW), and grip strength) and overall survival and a short-term outcome of 2-year progression to disability or death were evaluated. Cox proportional hazards and logistic regression models, stratified for metastatic disease, respectively, were used for outcomes.
Mean age was 77.2, 36.1% were women, and 45.7% were black. Faster 20-m usual walking speed was associated with a lower risk of death in the metastatic group (hazard ratio=0.89, 95% confidence interval (CI)=0.79-0.99) and lower 2-year progression to disability or death in the nonmetastatic group (odds ratio (OR)=0.77, 95% CI=0.64-0.94). Ability to complete the 400-m LDCW was associated with lower 2-year progression to disability or death in the nonmetastatic group (OR=0.24, 95% CI=0.10-0.62). There were no associations between grip strength and disability or death.
Lower extremity physical performance tests (usual gait speed and 400-m LDCW) were associated with survival and 2-year progression to disability or death. Objective physical performance measures may help inform pretreatment evaluations in older adults with cancer.
评估客观身体表现指标在预测癌症老年患者生存和随后残疾方面的作用。
纵向队列研究。
健康、衰老和身体成分（Health ABC）研究。
在 Health ABC 研究的前 6 年随访期间被诊断患有癌症的 429 人。
评估癌症前身体表现（20 米常速步行、400 米长距离走廊行走（LDCW）和握力）指标与总生存以及 2 年残疾或死亡进展的短期结果之间的关联。分别使用 Cox 比例风险和逻辑回归模型，按转移性疾病分层。
平均年龄为 77.2 岁，36.1%为女性，45.7%为黑人。20 米常速步行速度较快与转移性疾病组死亡风险降低相关（风险比=0.89，95%置信区间（CI）=0.79-0.99），非转移性疾病组 2 年残疾或死亡进展风险降低（优势比（OR）=0.77，95%CI=0.64-0.94）。完成 400 米 LDCW 的能力与非转移性疾病组较低的 2 年残疾或死亡进展相关（OR=0.24，95%CI=0.10-0.62）。握力与残疾或死亡之间没有关联。
下肢身体表现测试（常速步行和 400 米 LDCW）与生存和 2 年残疾或死亡进展相关。客观身体表现指标可能有助于为老年癌症患者的治疗前评估提供信息。
