微小 RNA：应对分子复杂性的捷径？
MicroRNAs: shortcuts in dealing with molecular complexity?
机构信息
King's College London, Department of Research Oncology, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 RT, UK.
出版信息
Breast Cancer Res. 2010;12(1):301. doi: 10.1186/bcr2455.
Abstract
Recent studies from Clarke's group published in the journal Cell indicate that miRNAs may be the elusive universal stem cell markers that the field of cancer stem cell biology has been seeking. Distinct profiles of miRNAs appear to reflect the state of cell differentiation not only in breast cancer cells, but also in normal mammary epithelial cells. Moreover, they are conserved across tissues and species. The authors of this work also show evidence that downregulation of miRNA-200c in normal and malignant breast stem cells and in embryonal carcinoma cells has functional relevance, being responsible for the proliferative potential of these cells in vitro and in vivo.
摘要
最近，克拉克小组在《细胞》杂志上发表的研究表明，miRNA 可能是癌症干细胞生物学领域一直在寻找的难以捉摸的通用干细胞标志物。miRNA 的不同特征似乎不仅反映了乳腺癌细胞的细胞分化状态，也反映了正常乳腺上皮细胞的分化状态。此外，它们在组织和物种之间是保守的。这项工作的作者还表明，miRNA-200c 在正常和恶性乳腺干细胞以及胚胎癌细胞中的下调具有功能相关性，负责这些细胞在体外和体内的增殖潜力。
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本文引用的文献
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