运动中的兴奋剂和兴奋剂滥用。

Stimulants and doping in sport.

机构信息

Institute of Biochemistry, Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany.

出版信息

Endocrinol Metab Clin North Am. 2010 Mar;39(1):89-105, ix. doi: 10.1016/j.ecl.2009.10.011.

DOI:10.1016/j.ecl.2009.10.011

PMID:20122452

Abstract

Stimulants have been frequently detected in doping control samples and represent a structurally diverse class of compounds. Comprehensive sports drug-testing procedures have been developed using gas or liquid chromatography combined with mass spectrometric detection, and they have revealed various adverse analytical findings, as demonstrated with 2 examples, 4-methylhexan-2-amine and methoxyphenamine. Moreover, the necessity of controlling the use or misuse of stimulating agents is outlined by means of pseudoephedrine, a compound that was prohibited in sports until the end of 2003. Since the ban was lifted, monitoring programs proved a significant increase in pseudoephedrine applications as determined from urine samples collected in competition. As a consequence, a reimplementation of this drug in future doping controls was decided.

摘要

兴奋剂在兴奋剂检测样本中经常被检出，代表了一类结构多样的化合物。使用气相色谱或液相色谱与质谱联用技术已经开发出了全面的运动药物检测程序，并且已经揭示了各种不良的分析结果，这可以通过 2 个实例，即 4-甲基己烷-2-胺和甲氧基苯丙胺来证明。此外，通过伪麻黄碱说明了控制兴奋剂的使用或滥用的必要性，这种化合物在 2003 年底之前在运动中被禁止。自从禁令解除以来，监测计划从比赛中收集的尿液样本中证明了伪麻黄碱的应用显著增加。因此，决定在未来的兴奋剂检测中重新使用这种药物。