CSIR Biosciences, Modderfontein 1645, South Africa.
Bioorg Med Chem. 2010 Feb 15;18(4):1406-14. doi: 10.1016/j.bmc.2010.01.025. Epub 2010 Jan 18.
Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalysed by an immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35 degrees C) in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated p-benzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and/or 5-lipoxygenase inhibiting activity.
用诺维信公司的固定化商业漆酶 Denilite II Base 催化对苯二酚与芳香族和脂肪族伯胺的硝化反应，在反应容器中温和条件下（室温，35℃），在空气存在下，漆酶和共溶剂存在下，使伯胺与对苯二酚反应，仅得到二氨基对苯醌。这些化合物可能具有抗过敏、抗生素、抗癌、抗真菌、抗病毒和/或 5-脂氧合酶抑制活性。
