抗坏血酸对实验性慢性砷中毒啮齿动物血液氧化应激的影响。
Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents.
机构信息
Indian Veterinary Research Institute, Eastern Regional Station, 37, Belgachia Road, Kolkata 700 037, India.
出版信息
Food Chem Toxicol. 2010 Apr;48(4):1072-7. doi: 10.1016/j.fct.2010.01.027. Epub 2010 Feb 1.
Ascorbic acid is a sugar acid and an essential vital food nutrient found mainly in fruits and vegetables. The purpose of this study was to investigate the effects of ascorbic acid against arsenic induced oxidative stress in blood of rat. In rat, treatment with ascorbic acid prevented the increased serum enzymatic activity of AST, ALT, ALP, ACP and LDH. In addition, treatment with ascorbic acid prevented elevated production of LPO, PC and NO and restored the depletion of reduced SOD and CAT activities. Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-oxidative activity in the blood.
抗坏血酸是一种糖酸，也是主要存在于水果和蔬菜中的必需生命营养物质。本研究旨在探讨抗坏血酸对大鼠血液砷诱导的氧化应激的影响。在大鼠中，抗坏血酸治疗可预防血清 AST、ALT、ALP、ACP 和 LDH 酶活性的增加。此外，抗坏血酸治疗可防止 LPO、PC 和 NO 的产生增加，并恢复因砷处理而减少的 SOD 和 CAT 活性。有趣的是，抗坏血酸显著上调了淋巴细胞相对于 GAPDH 的 SOD2 基因的相对 mRNA 表达，GAPDH 是砷处理大鼠中管家候选基因，这可能为血液提供抗氧化活性。
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