Ashar Hena R, Chouinard Roland A, Dokur Madhavi, Chada Kiran
HMGene, Inc. 675 US Highway One, North Brunswick, NJ 08902, USA.
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):55-61. doi: 10.1016/j.bbagrm.2009.11.013.
While the biochemical role of the HMGA proteins has largely been elucidated in tissue culture, the majority of the insight as to their physiological functions in the processes of proliferation and development has been established in animal models of overexpression (transgenic) and null mice (knockouts). An emphasis has been placed on the HMGA2 studies which have defined its critical role in mesenchymal proliferation and differentiation.
虽然HMGA蛋白的生化作用在组织培养中已基本阐明，但关于它们在增殖和发育过程中的生理功能的大部分见解是在过表达（转基因）动物模型和基因敲除小鼠模型中获得的。研究重点一直放在HMGA2上，这些研究确定了它在间充质增殖和分化中的关键作用。
