Pata Janice D
Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.
Biochim Biophys Acta. 2010 May;1804(5):1124-35. doi: 10.1016/j.bbapap.2010.01.020. Epub 2010 Feb 1.
The Y-family translesion DNA polymerases enable cells to tolerate many forms of DNA damage, yet these enzymes have the potential to create genetic mutations at high rates. Although this polymerase family was defined less than a decade ago, more than 90 structures have already been determined so far. These structures show that the individual family members bypass damage and replicate DNA with either error-free or mutagenic outcomes, depending on the polymerase, the lesion and the sequence context. Here, these structures are reviewed and implications for polymerase function are discussed.
Y 家族跨损伤 DNA 聚合酶使细胞能够耐受多种形式的 DNA 损伤，但这些酶有产生高频率基因突变的可能性。尽管这个聚合酶家族在不到十年前才被定义，但到目前为止已经确定了 90 多个结构。这些结构表明，根据聚合酶、损伤类型和序列背景，各个家族成员会绕过损伤并复制 DNA，结果可能是无差错的，也可能是诱变的。本文对这些结构进行了综述，并讨论了其对聚合酶功能的影响。
