Furue H
Dept. of Internal Medicine, Mizonokuchi Hospital, Teikyo University, School of Medicine.
Gan To Kagaku Ryoho. 1991 Apr;18(4):529-34.
Progress in the treatment of cancer with drugs has altered the clinical approach to patients with cancer. However, chemotherapy used as sole treatment for colorectal cancer has not been generally successful in providing palliation or improving patient life span. This article describes the recent new efforts to improve the effectiveness of chemotherapy: including combination chemotherapy, biochemical modulation, combination of 5-fluorouracil and interferon, quality of life assessment in chemotherapy, and clinical issues of adjuvant chemotherapy. However, available data from these studies dose not establish a true therapeutic advance in the treatment of colorectal cancer, and do provide a strong scientific rationale for well-controlled randomized clinical trials. Furthermore, there is a strong imperative for the development of new therapeutic strategies in this disease.
药物治疗癌症方面的进展已经改变了对癌症患者的临床治疗方法。然而，将化疗作为结直肠癌的唯一治疗方法，在提供缓解症状或延长患者寿命方面总体上并不成功。本文介绍了近期为提高化疗效果所做的新努力：包括联合化疗、生化调节、5-氟尿嘧啶与干扰素联合、化疗中的生活质量评估以及辅助化疗的临床问题。然而，这些研究的现有数据并未证实结直肠癌治疗有真正的治疗进展，但确实为开展严格控制的随机临床试验提供了有力的科学依据。此外，在这种疾病中开发新的治疗策略有着强烈的迫切需求。
