Harder F, Laffer U, Berres M, Jäggi P, Metzger U
Departement Chirurgie, Universität, Kantonsspital Basel.
Chirurg. 1990 Apr;61(4):280-5.
After curative resection of colorectal cancer, immediate short-term postoperative intraportal adjuvant chemotherapy reduces the relative risk of recurrence and death in the non-transfused patient significantly, when compared to transfused patients without chemotherapy. This is demonstrated in a multivariate analysis using the Cox model on a group of 469 patients who have been intraoperatively randomized to receive either intraportal chemotherapy for 7 days or no further treatment. The transfused patients with chemotherapy and those receiving neither transfusions nor chemotherapy had a relative risk of recurrence and death situated in between the two groups mentioned above, not statistically different from either of them. In the setting of this study, 7 days postoperative intraportal chemotherapy seems particularly effective in the non-transfused patients.
在结直肠癌根治性切除术后，与未接受化疗的输血患者相比，术后立即进行短期门静脉内辅助化疗可显著降低未输血患者复发和死亡的相对风险。这在一项多变量分析中得到了证实，该分析使用Cox模型对一组469例患者进行研究，这些患者在术中被随机分为接受7天门静脉内化疗或不再接受进一步治疗。接受化疗的输血患者以及既未输血也未接受化疗的患者，其复发和死亡的相对风险介于上述两组之间，与其中任何一组相比均无统计学差异。在本研究的背景下，术后7天门静脉内化疗似乎对未输血患者特别有效。
