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Ca2+ cycling and new therapeutic approaches for heart failure.

作者信息

Lompré Anne-Marie, Hajjar Roger J, Harding Sian E, Kranias Evangelia G, Lohse Martin J, Marks Andrew R

机构信息

INSERM UMRS956/Université Pierre et Marie Curie, Faculté de Médecine, 91 Boulevard de l'Hôpital, 75013 Paris, France.

出版信息

Circulation. 2010 Feb 16;121(6):822-30. doi: 10.1161/CIRCULATIONAHA.109.890954. Epub 2010 Feb 1.

DOI:10.1161/CIRCULATIONAHA.109.890954
PMID:20124124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2834781/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88a8/2834781/4cd6c02e2692/nihms-172827-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88a8/2834781/4cd6c02e2692/nihms-172827-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88a8/2834781/4cd6c02e2692/nihms-172827-f0001.jpg

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本文引用的文献

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Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.小鼠从压力超负荷诱导的心肌肥厚向心力衰竭转变过程中钙调蛋白依赖性蛋白激酶II的需求
J Clin Invest. 2009 May;119(5):1230-40. doi: 10.1172/JCI38022. Epub 2009 Apr 20.
2
Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart.来自衰竭的人类和大鼠心脏的心室肌细胞中T小管的丧失及表面形态的其他变化。
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6854-9. doi: 10.1073/pnas.0809777106. Epub 2009 Apr 2.
3
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.经皮基因治疗上调心脏病患者钙水平（CUPID试验），一项首次人体1/2期临床试验。
J Card Fail. 2009 Apr;15(3):171-81. doi: 10.1016/j.cardfail.2009.01.013.
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Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.连接蛋白的部分下调可增强心脏钙循环，且不会在小鼠中引发室性心律失常。
Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1484-90. doi: 10.1152/ajpheart.00229.2008. Epub 2009 Mar 13.
5
Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology.蛋白磷酸酶1（PP1）在心脏生理和病理生理过程中钙循环调节中的作用
Front Biosci (Landmark Ed). 2009 Jan 1;14(9):3571-85. doi: 10.2741/3472.
6
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.长期心脏靶向RNA干扰治疗心力衰竭可恢复心脏功能并减轻病理性肥大。
Circulation. 2009 Mar 10;119(9):1241-52. doi: 10.1161/CIRCULATIONAHA.108.783852. Epub 2009 Feb 23.
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Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle.高亚硝基化的兰尼碱受体钙释放通道在营养不良性肌肉中存在渗漏。
Nat Med. 2009 Mar;15(3):325-30. doi: 10.1038/nm.1916. Epub 2009 Feb 8.
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Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.受磷蛋白功能的改变可表现出心脏毒性作用，而与过度抑制肌浆网Ca2+-ATP酶无关。
Circulation. 2009 Jan 27;119(3):436-44. doi: 10.1161/CIRCULATIONAHA.108.783506. Epub 2009 Jan 12.
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Nat Clin Pract Cardiovasc Med. 2008 Sep;5(9):554-65. doi: 10.1038/ncpcardio1301. Epub 2008 Jul 29.