Alsheikh Raneem, Aldulaimi Haneen, Hinawi Rami, Al-Sadi Fatima, Al-Baker Alanoud, Alkuwari Aldana, Sameer Muhammad, Al-Abdulla Ghalya, Shi Zumin, Rathnaiah Babu Giridhara
College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
Nutr Metab (Lond). 2025 Jan 30;22(1):8. doi: 10.1186/s12986-024-00892-y.
Metabolic syndrome (MetS) and its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. Although Magnesium (Mg) and Calcium (Ca) have been individually linked to MetS, the impact of the calcium-to-magnesium ratio (Ca: Mg) on MetS remains unclear, especially in the adult population of Qatar. In this study, we aim to investigate the association between the total serum concentrations of Ca, Mg and Ca: Mg ratio with the outcome of MetS.
This comprehensive cross-sectional study included data on 9693 participants collected by Qatar Biobank (QBB). The serum levels of Mg and Ca, in addition to recorded metabolic parameters for the study participants, were used in the analyses. The presence of MetS was deemed as our primary outcome and its components as secondary outcomes. Logistic regression models were run to examine these associations.
MetS was present in more than 19% of the population. The mean serum Mg was higher in the non-MetS group 0.83 ± 0.06 mmol/L compared to the MetS group 0.81 ± 0.08 mmol/L. Conversely, the mean serum Ca and Ca: Mg ratio were higher in the MetS group (2.33 ± 0.09 mmol/L, 2.92 ± 0.36 mmol/L) compared to the non-MetS group (2.30 ± 0.08 mmol/L, 2.77 ± 0.23 mmol/L) respectively. In the context of MetS, we observed a negative dose-response relationship between Mg quartiles and MetS. In contrast, we found a positive association between Ca as well as Ca: Mg ratio and MetS.
代谢综合征（MetS）及其合并症，连同矿物质失衡，给卡塔尔人群带来了重大的健康负担。尽管镁（Mg）和钙（Ca）分别与MetS相关，但钙镁比（Ca:Mg）对MetS的影响仍不清楚，尤其是在卡塔尔的成年人群体中。在本研究中，我们旨在调查血清中钙、镁的总浓度以及钙镁比与MetS结局之间的关联。
这项全面的横断面研究纳入了卡塔尔生物样本库（QBB）收集的9693名参与者的数据。分析中使用了参与者的血清镁和钙水平，以及记录的代谢参数。MetS的存在被视为主要结局，其组成部分被视为次要结局。使用逻辑回归模型来检验这些关联。
超过19%的人群患有MetS。非MetS组的平均血清镁（0.83±0.06 mmol/L）高于MetS组（0.81±0.08 mmol/L）。相反，MetS组的平均血清钙和钙镁比（分别为2.33±0.09 mmol/L，2.92±0.36 mmol/L）高于非MetS组（2.30±0.08 mmol/L，2.77±0.23 mmol/L）。在MetS的背景下，我们观察到镁四分位数与MetS之间存在负剂量反应关系。相比之下，我们发现钙以及钙镁比与MetS之间存在正相关。
