Nishikawa Satomi, Sano Fumiko, Takagi Kan, Okada Miyoko, Sugimoto Jiro, Takagi Shiro
Mitsubishi Tanabe Pharma Corporation-Safety Research Laboratory, Kisarazu, Japan.
Toxicol Pathol. 2010 Feb;38(2):315-8. doi: 10.1177/0192623309358905. Epub 2010 Feb 2.
Spontaneous salivary gland tumors in rats are rare. The authors report a poorly differentiated carcinoma of a submandibular gland in a ten-week-old rat that was positive for vimentin. Microscopically, the neoplastic cells showed a diffuse growth pattern in most areas of the tumor mass and a nestlike structure in a part of the peripheral area. Immunohistochemically, the cells were positive for keratin and vimentin but not for alpha-smooth muscle actin. Ultrastructurally, desmosome-like structures were observed. Based on these findings, the tumor was diagnosed as a poorly differentiated carcinoma. The origin of the neoplastic cells would be either acinar or ductal cells. This suggests that acinar or ductal cells have the potential to transform into vimentin-expressing cells.
大鼠自发性唾液腺肿瘤很罕见。作者报告了一只10周龄大鼠的下颌下腺低分化癌，波形蛋白呈阳性。显微镜下，肿瘤细胞在肿瘤块的大部分区域呈弥漫性生长模式，在外周部分区域呈巢状结构。免疫组化显示，细胞角蛋白和波形蛋白呈阳性，而α-平滑肌肌动蛋白呈阴性。超微结构观察到类桥粒结构。基于这些发现，该肿瘤被诊断为低分化癌。肿瘤细胞的起源可能是腺泡细胞或导管细胞。这表明腺泡或导管细胞有可能转化为表达波形蛋白的细胞。
