Duell P B, Chesnut C H
Department of Medicine, University of Washington, Seattle 98195.
Arch Intern Med. 1991 Apr;151(4):783-4.
Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis. Unfortunately, the high frequency of side effects may limit the use of this treatment modality. This report documents the repeated exacerbation of rheumatoid arthritis on three occasions after the initiation of sodium fluoride therapy. This apparent complication of sodium fluoride treatment may be mediated by stimulation of leukocyte production of reactive oxygen species and other mediators of the acute inflammatory response. We suggest that sodium fluoride should be used cautiously in patients with rheumatoid arthritis.
最近的研究表明，氟化钠疗法可能是治疗椎体骨质疏松症的一种有效方法。不幸的是，高频率的副作用可能会限制这种治疗方式的使用。本报告记录了在开始氟化钠治疗后三次类风湿关节炎反复加重的情况。氟化钠治疗的这种明显并发症可能是由刺激白细胞产生活性氧和急性炎症反应的其他介质介导的。我们建议，类风湿关节炎患者应谨慎使用氟化钠。
