Department of Pediatrics, The Sahlgrenska Academy, University of Gothenburg, Sweden.
Transplantation. 2010 Mar 15;89(5):606-11. doi: 10.1097/TP.0b013e3181ca7b04.
Acute oral angioedema is well documented in young pediatric liver-transplanted patients. This is a report of an identified novel entity of long-standing oral mucosal lesions (OML) in children who had undergone solid organ transplantation.
In conjunction with routine medical follow-ups, all solid organ-transplanted children were examined annually for OML.
Eight children developed a novel entity of long-standing OML after solid organ transplantation. Seven of the eight children had undergone liver transplantation whereas one child was kidney transplanted. The children received tacrolimus immunosuppression after transplantation. All recipients presented with multiple spherical nodules on the dorsum of the tongue, which later on displayed a fissured appearance. Most patients also presented with mucosal tags or ridges and swollen lips similar to those found in patients with orofacial granulomatosis. In addition, most patients had a clinical history of immediate-onset food-induced allergic reactions, including transient angioedema, after transplantation, but this clinical manifestation appeared separately from the long-standing lesions.
A novel entity of long-standing OML that share some features with orofacial granulomatosis has been identified in children after solid organ transplantation.
急性口腔血管性水肿在年轻的肝移植儿科患者中已有充分记录。本文报告了一种在接受实体器官移植的儿童中发现的口腔黏膜病变（OML）的新实体。
在常规医疗随访的同时，对所有接受实体器官移植的儿童每年进行一次 OML 检查。
8 名儿童在接受实体器官移植后出现了一种新的长期 OML 实体。8 名儿童中有 7 名接受了肝移植，1 名接受了肾移植。儿童在移植后接受了他克莫司免疫抑制治疗。所有受者的舌背均出现多个球形结节，随后呈现出裂隙状外观。大多数患者还表现出类似口腔肉芽肿病患者的黏膜小结或嵴以及肿胀的嘴唇。此外，大多数患者在移植后都有即时食物诱导过敏反应的临床病史，包括短暂的血管性水肿，但这种临床表现与长期病变分开出现。
在接受实体器官移植的儿童中，已经确定了一种与口腔肉芽肿病具有某些特征的新型长期 OML 实体。
