Gašpar Marija, Glavina Ana, Grubišić Kristina, Sabol Ivan, Bušić Mirela, Mravak Marinka
Department of Oral medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Rudjer Bošković Institute, Zagreb, Croatia.
Acta Stomatol Croat. 2015 Sep;49(3):204-13. doi: 10.15644/asc49/3/2.
Patients with a solid organ transplant can have many different complications in the mouth, as a result of immunosuppression and side effects of drugs. The aim of this study was to examine the frequency and type of oral lesions in renal transplant patients, dental status, oral hygiene, oral lesions related to drugs which patients take and the time of transplantation as well as the frequency of patient's visits to the dentist in the post-transplant period.
The study was performed in a period of two years and included 100 subjects with a renal transplant during their regular control visits to the Department of Nephrology and Dialysis, Clinical Hospital Centre Zagreb and the Department of Oral Medicine, School of Dental Medicine, University of Zagreb and 100 randomly selected control subjects at the Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb.
Results showed a significantly higher incidence of oral lesions in patients with renal transplant (31%) compared to control subjects. The most frequent were erythematous (inflammatory changes), keratotic lesions and gingival hyperplasia. The average DMFT index was significantly lower in patients with renal transplant than in the control group. One third of patients had a subjective feeling of dry mouth. Oral hygiene was poor overall, and only a small number of subjects used the additional sustainers for oral hygiene. Most patients did not visit the dentist after the transplantation.
Renal transplant patients need a comprehensive and regular dental care during the pre- and post-transplant period and a doctor of dental medicine should be part of a multidisciplinary team of medical specialists.
由于免疫抑制和药物副作用,实体器官移植患者口腔可能出现多种不同并发症。本研究旨在调查肾移植患者口腔病变的频率和类型、牙齿状况、口腔卫生、与患者所服用药物相关的口腔病变、移植时间以及移植后患者看牙医的频率。
本研究历时两年,纳入了100名在萨格勒布临床医院中心肾病与透析科以及萨格勒布大学牙医学院口腔医学系进行定期复查的肾移植患者,以及100名在萨格勒布大学牙医学院牙髓病与修复牙科系随机选取的对照受试者。
结果显示,肾移植患者口腔病变的发生率(31%)显著高于对照受试者。最常见的是红斑(炎症改变)、角化病变和牙龈增生。肾移植患者的平均DMFT指数显著低于对照组。三分之一的患者有口干的主观感觉。总体口腔卫生较差,只有少数受试者使用额外的口腔卫生辅助用品。大多数患者在移植后未看牙医。
肾移植患者在移植前和移植后期间需要全面、定期的牙科护理,牙科医生应成为多学科医学专家团队的一员。