基于相位近似模型的生物发光断层成像
Bioluminescence tomography based on the phase approximation model.
作者信息
Cong W, Wang G
机构信息
Biomedical Imaging Division, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Stanger Street, Blacksburg, Virginia 24061, USA.
出版信息
J Opt Soc Am A Opt Image Sci Vis. 2010 Feb 1;27(2):174-9. doi: 10.1364/JOSAA.27.000174.
Abstract
A reconstruction method of bioluminescence sources is proposed based on a phase approximation model. Compared with the diffuse approximation, this phase approximation model more correctly predicts bioluminescence photon propagation in biological tissues, so that bioluminescence tomography can accurately locate and quantify the distribution of bioluminescence sources. The compressive sensing (CS) technique is applied to regularize the inverse source reconstruction to enhance numerical stability and efficiency. The numerical simulation and phantom experiments demonstrate the feasibility of the proposed approach.
摘要
提出了一种基于相位近似模型的生物发光源重建方法。与扩散近似相比，该相位近似模型能更准确地预测生物发光光子在生物组织中的传播，从而使生物发光断层成像能够准确地定位和量化生物发光源的分布。应用压缩感知（CS）技术对源重建反问题进行正则化处理，以提高数值稳定性和效率。数值模拟和体模实验验证了该方法的可行性。
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