Department of Neuroscience, Erasmus Medical Center, Rotterdam The Netherlands.
Front Cell Neurosci. 2010 Jan 4;3:19. doi: 10.3389/neuro.03.019.2009. eCollection 2010.
Over the past decade the advent of mouse transgenics has generated new perspectives on the study of cerebellar molecular mechanisms that are essential for eyeblink conditioning. However, it also appears that results from eyeblink conditioning experiments done in mice differ in some aspects from results previously obtained in other mammals. In this review article we will, based on studies using (cell-specific) mouse mutants and region-specific lesions, re-examine the general eyeblink behavior in mice and the neuro-anatomical circuits that might contribute to the different peaks in the conditioned eyeblink trace. We conclude that the learning process in mice has at least two stages: An early stage, which includes short-latency responses that are at least partly controlled by extracerebellar structures such as the amygdala, and a later stage, which is represented by well-timed conditioned responses that are mainly controlled by the pontocerebellar and olivocerebellar systems. We refer to this overall concept as the Amygdala-Cerebellum-Dynamic-Conditioning Model (ACDC model).
在过去的十年中，小鼠转基因技术的出现为研究小脑分子机制提供了新的视角，这些机制对于眨眼条件反射至关重要。然而，似乎在小鼠中进行的眨眼条件反射实验的结果在某些方面与以前在其他哺乳动物中获得的结果有所不同。在这篇综述文章中，我们将基于使用（细胞特异性）小鼠突变体和区域特异性损伤的研究，重新检查小鼠的一般眨眼行为以及可能有助于条件反射眨眼轨迹中不同峰值的神经解剖回路。我们得出结论，小鼠的学习过程至少有两个阶段：一个早期阶段，包括潜伏期较短的反应，这些反应至少部分由杏仁核等脑外结构控制；另一个后期阶段，由时机良好的条件反应表示，主要由桥脑小脑和橄榄小脑系统控制。我们将这个整体概念称为杏仁核-小脑-动态-条件反射模型（ACDC 模型）。
