Schreurs Bernard G, O'Dell Deidre E, Wang Desheng
Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USA.
Department of Biology, Earth and Environmental Sciences, Pennsylvania Western (PennWest) University, California, PA 15419, USA.
Biology (Basel). 2024 Mar 21;13(3):200. doi: 10.3390/biology13030200.
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets-mesh-like structures that surround neurons-in the brain, and it appears there may be a connection between these nets and cognitive processes, particularly learning and memory. Here, we review how the cerebellum is involved in eyeblink conditioning-a particularly well-understood form of learning and memory-and focus on the role of perineuronal nets in intrinsic membrane excitability and synaptic plasticity that underlie eyeblink conditioning. We explore the development and role of perineuronal nets and the in vivo and in vitro evidence that manipulations of the perineuronal net in the deep cerebellar nuclei affect eyeblink conditioning. Together, these findings provide evidence of an important role for perineuronal net in learning and memory.
有充分证据表明，除了精细运动控制外，小脑在认知和情感方面也发挥着重要作用。哺乳动物小脑的深部核团还包含大脑中神经周网（围绕神经元的网状结构）密度最高的区域，而且这些神经周网与认知过程，尤其是学习和记忆之间似乎存在联系。在此，我们回顾小脑如何参与眨眼条件反射（一种对学习和记忆理解得较为透彻的形式），并着重探讨神经周网在眨眼条件反射所依赖的内在膜兴奋性和突触可塑性中的作用。我们探究神经周网的发育及其作用，以及体内和体外实验证据，即对小脑深部核团中的神经周网进行操作会影响眨眼条件反射。这些研究结果共同证明了神经周网在学习和记忆中的重要作用。
