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使用α受体阻滞剂的副作用：逆行射精。

Side Effects of alpha-Blocker Use: Retrograde Ejaculation.

作者信息

Kaplan Steven A

机构信息

Institute for Bladder and Prostate Health, Weill Cornell Medical College of Cornell University New York, NY.

出版信息

Rev Urol. 2009 Fall;11(Suppl 1):S14-8.

PMID:20126607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2812888/
Abstract

There are currently 5 alpha-blockers that are approved by the US Food and Drug Administration to treat lower urinary tract symptoms (LUTS). The American Urological Association guidelines committee believes that all alpha-blockers are equally effective. However, alpha-blockers differ in their likelihood of causing abnormal ejaculation. This article discusses the effects on ejaculatory function, and specifically retrograde ejaculation, of the currently available alpha-blockers being used to treat men with LUTS due to benign prostatic hyperplasia.

摘要

目前有5种α受体阻滞剂已获美国食品药品监督管理局批准用于治疗下尿路症状（LUTS）。美国泌尿外科学会指南委员会认为，所有α受体阻滞剂的疗效相当。然而，不同α受体阻滞剂导致异常射精的可能性存在差异。本文探讨了目前用于治疗因良性前列腺增生导致下尿路症状的男性患者的α受体阻滞剂对射精功能的影响，特别是逆行射精的影响。

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本文引用的文献

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Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies.高选择性α1A肾上腺素能受体拮抗剂西洛多辛对有良性前列腺增生体征和症状男性的快速疗效：两项3期研究的汇总结果
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Pharmacology of alpha1-adrenoceptor antagonists in the lower urinary tract and central nervous system.α1肾上腺素能受体拮抗剂在下尿路及中枢神经系统中的药理学
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Alpha1-adrenoceptors and ejaculatory function.α1肾上腺素能受体与射精功能。
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Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers.坦索罗辛与阿夫唑嗪急性治疗对正常志愿者射精功能的影响。
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Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men.西洛多辛，一种用于治疗良性前列腺增生的新型α1A肾上腺素能受体选择性拮抗剂：在日本男性中进行的III期随机、安慰剂对照、双盲研究结果
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[Alpha1-adrenoceptor subtype selectivity and organ specificity of silodosin (KMD-3213)].[西洛多辛（KMD-3213）的α1-肾上腺素能受体亚型选择性和器官特异性]
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Tamsulosin 0.4 mg once daily: effect on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction.坦索罗辛0.4毫克，每日一次：对提示良性前列腺梗阻的下尿路症状患者性功能的影响。
Eur Urol. 1999 Oct;36(4):335-41. doi: 10.1159/000019996.