磷钼酸催化的温和、高效 Nazarov 环化反应。
A mild, catalytic and efficient Nazarov cyclization mediated by phosphomolybdic acid.
机构信息
Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan, Republic of China.
出版信息
Chem Commun (Camb). 2010 Feb 21;46(7):1127-9. doi: 10.1039/b918137g. Epub 2009 Dec 24.
DOI:10.1039/b918137g
PMID:20126735
Abstract
A mild, selective and efficient Nazarov cyclization of divinyl ketones catalyzed by phosphomolybdic acid (PMA) is described. The process demonstrates a broad substrate scope with functional group tolerance under short reaction times. PMA supported on silica gel is more efficient than the bulk catalyst and is recycled up to three times without significant activity loss.
摘要
描述了由磷钼酸（PMA）催化的二乙烯基酮的温和、选择性和高效的 Nazarov 环化反应。该过程在短反应时间内表现出广泛的底物范围和官能团耐受性。负载在硅胶上的 PMA 比体相催化剂更有效，并且可以回收三次而没有明显的活性损失。
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