Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Chem Commun (Camb). 2010 Feb 21;46(7):1156-8. doi: 10.1039/b912396b. Epub 2010 Jan 4.
Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Abeta(1-42) fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically.
将噻唑橙与 Abeta(1-42) 纤维肽模型结合的 X 射线数据与理论计算相结合，为主要稳定相互作用提供了证据，这些相互作用影响噻唑橙两个部分之间的二面角，从而影响其荧光特性；这些结果为设计更特异性结合淀粉样纤维的染料的可能策略提供了新的线索。
