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[前列腺中的雄激素和雌激素调节:以啮齿动物实验模型为重点的结构生物学研究方法]

[Androgenic and estrogenic modulation in the prostate: an approach in rodent experimental models with emphasis on structural biology].

作者信息

Taboga Sebastião Roberto, Vilamaior Patricia Simone Leite, Góes Rejane Maira

机构信息

Departamento de Biologia, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista, São José do Rio Preto, SP, Brasil.

出版信息

Arq Bras Endocrinol Metabol. 2009 Nov;53(8):946-55. doi: 10.1590/s0004-27302009000800007.

Abstract

The endocrine system is a complex network of glands and hormones that regulates many of the body's functions; including growth, development and maturation, as well as the way several organs operate. The prostate is an important target of hormones and its functional maturity and development are influenced by steroids levels. Our research group has been evaluating the potential effects of the steroidal agents on the Mongolian gerbil (Meriones unguiculatus) male and female prostate using different morphological and immunohistochemical methods. Our results have revealed the Mongolian gerbil prostate as an important tool for the morphofunctional studies of steroid hormones and its antagonist actions.

摘要

内分泌系统是一个由腺体和激素组成的复杂网络,它调节身体的许多功能,包括生长、发育和成熟,以及多个器官的运作方式。前列腺是激素的重要靶器官,其功能成熟和发育受类固醇水平的影响。我们的研究小组一直在使用不同的形态学和免疫组织化学方法评估类固醇药物对雄性和雌性长爪沙鼠(Meriones unguiculatus)前列腺的潜在影响。我们的研究结果表明,长爪沙鼠前列腺是研究类固醇激素及其拮抗作用的形态功能的重要工具。

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