Russo Luis Augusto Tavares, Gregório Luiz Henrique de, Lacativa Paulo Gustavo Sampaio, Marinheiro Lizanka Paola F
Brasil Centro de Pesquisas Clínica, Rio de Janeiro, RJ, Brasil.
Arq Bras Endocrinol Metabol. 2009 Dec;53(9):1079-87. doi: 10.1590/s0004-27302009000900004.
This study was designed to determine mean serum concentrations of 25-hydroxyvitamin D (25OHD) in postmenopausal women with low bone mineral density (BMD), to find the cutoff of parathormone (PTH) elevation, and to evaluate the correlation 25OHD with BMD, biochemical parameters and vertebral fracture presence.
Transversal study, with collection of 25OHD and PTH, and determination of DMO and column radiograph.
A high incidence of inadequate serum concentrations of 25OHD (68.3%) was found and 8% of secondary hyperparathyreoidism. No significant differences were found between 25OHD serum concentrations and the evaluated parameters, except for PTH, which showed a negative association. The established cutoff was 61.5 nmol/L.
The elevated incidence of hipovitaminosis D in elderly women with low BMD suggests that a systematic evaluation of 25OHD serum concentrations must be done for this population.The use of 61.5 nmol/L as a cutoff is recommended until the realization of an epidemiologic study that represents all Rio de Janeiro city (RJ, Brazil).
本研究旨在测定骨密度（BMD）低的绝经后女性血清25-羟维生素D（25OHD）的平均浓度，找出甲状旁腺激素（PTH）升高的临界值，并评估25OHD与骨密度、生化参数及椎体骨折存在情况之间的相关性。
横断面研究，收集25OHD和PTH，并测定双能X线吸收法（DMO）和脊柱X线片。
发现血清25OHD浓度不足的发生率很高（68.3%），继发性甲状旁腺功能亢进的发生率为8%。除PTH呈负相关外，25OHD血清浓度与评估参数之间未发现显著差异。确定的临界值为61.5 nmol/L。
骨密度低的老年女性维生素D缺乏症发生率升高，表明必须对该人群进行血清25OHD浓度的系统评估。在开展一项代表整个巴西里约热内卢市（RJ）的流行病学研究之前，建议将61.5 nmol/L用作临界值。
