Rêgo Amália Cínthia Meneses do, Araújo-Filho Irami, Azevedo Italo Medeiros, Jácome Daniel Tôrres, Ramalho Rachel de Alcântara Oliveira, Medeiros Aldo Cunha
Department of Surgery, School of Medicine, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.
Acta Cir Bras. 2010 Feb;25(1):9-12. doi: 10.1590/s0102-86502010000100004.
The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.
Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1 mL of Na(99m)Tc(-) via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant.
Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups.
This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na(99m)Tc(-).
