Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats.

作者信息

Rêgo Amália Cínthia Meneses do, Araújo-Filho Irami, Azevedo Italo Medeiros, Jácome Daniel Tôrres, Ramalho Rachel de Alcântara Oliveira, Medeiros Aldo Cunha

机构信息

Department of Surgery, School of Medicine, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.

出版信息

Acta Cir Bras. 2010 Feb;25(1):9-12. doi: 10.1590/s0102-86502010000100004.

DOI:10.1590/s0102-86502010000100004

PMID:20126880

Abstract

PURPOSE

The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.

METHODS

Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1 mL of Na(99m)Tc(-) via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant.

RESULTS

Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups.