Holanda Cecília Maria de Carvalho Xavier, Costa Monique Batista da, Silva Natália Chilinque Zambão da, Silva Maurício Ferreira da, Barbosa Vanessa Santos de Arruda, Silva Roseane Pereira da, Medeiros Aldo da Cunha
Department of Microbiology and Parasitology, UFRN, Brazil.
Acta Cir Bras. 2009 Sep-Oct;24(5):383-6. doi: 10.1590/s0102-86502009000500008.
Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na99mTcO4 and laboratorial parameters in Wistar rats.
Twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na99mTcO4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (%ATI/g) was determined. Biochemical dosages were performed.
There was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p<0.05).
The aqueous extract of Aloe vera facilitated the uptake of Na99mTcO4 in organs of rats and it was responsible to a high increase of levels of AST and ALT.
芦荟是一种热带植物，在巴西俗称巴巴苏。我们研究了芦荟水提取物对Wistar大鼠体内99mTcO4Na生物分布及实验室参数的影响。
将12只动物分为治疗组和对照组。治疗组在10天内通过灌胃给予芦荟（5mg/mL/天）。对照组在相同时间内以相同方式给予山梨醇。最后一次给药1小时后，通过眶丛注射0.1mL 99mTcO4Na。60分钟后，处死所有动物。从脑、肝、心、肌肉、胰腺、胃、股骨、肾、血、睾丸和甲状腺采集样本，测定放射性百分比（%ATI/g）。进行生化检测。
血液、股骨、肾、肝、胃、睾丸和甲状腺中的%ATI/g以及AST和ALT的血液水平显著升高。葡萄糖、胆固醇、甘油三酯、肌酐和尿素水平显著降低。采用Mann-Whitney检验和T检验进行统计分析（p<0.05）。
芦荟水提取物促进了大鼠器官对99mTcO4Na的摄取，并导致AST和ALT水平大幅升高。
