Research Center, EMESCAM Medical School, Vitoria, ES, Brazil.
Obes Surg. 2011 Jan;21(1):71-7. doi: 10.1007/s11695-010-0080-8. Epub 2010 Feb 2.
Accumulated fat is an accepted trigger of inflammation and metabolic syndrome but specific biochemical associations in males and females are still debated. In a prospective study, multiple variables were analyzed to search for gender-related correlations.
Bariatric candidates (n = 94) were consecutively investigated. Age was 34.9 ± 10.4 years (68.1% females) and body mass index (BMI) was 40.8 ± 4.6 kg/m(2). Methods included anthropometrics, inflammatory indices (C-reactive protein (CRP), white blood cell count (WBC), ferritin) and general biochemical profile.
Ferritin, but not CRP or WBC, was substantially more elevated in males. Serum albumin, uric acid, creatinine, and liver enzymes AST and ALT were also higher in men. Even after BMI was adjusted, all differences remained significant, and several, notably ferritin, withstood waist circumference control. Ferritin and CRP correlated with anthropometrics, glucose-related measurements, and liver enzymes, whereas WBC was only associated with triglycerides in females.
(1) Males displayed more severe inflammation according to ferritin profile, and also more signs of liver derangement; (2) all differences continued after BMI discrepancies were adjusted for, and ferritin was significant also after control of waist girth; (3) in both genders inflammatory markers often correlated with different anthropometrics, liver enzymes, and markers of glucose homeostasis; and (4) inflammatory and biochemical gender-related dissimilarities might have prognostic implications for cardiovascular risk and other comorbidities, and deserve additional studies.
积累的脂肪是炎症和代谢综合征的公认诱因，但男性和女性之间的具体生化关联仍存在争议。在一项前瞻性研究中，分析了多个变量以寻找与性别相关的相关性。
连续研究了 94 名减肥候选人。年龄为 34.9 ± 10.4 岁（女性占 68.1％），体重指数（BMI）为 40.8 ± 4.6 kg/m²。方法包括人体测量学，炎症指标（C 反应蛋白（CRP），白细胞计数（WBC），铁蛋白）和一般生化特征。
男性的铁蛋白明显升高，但 CRP 或 WBC 没有明显升高。血清白蛋白，尿酸，肌酐和肝酶 AST 和 ALT 也较高。即使调整 BMI 后，所有差异仍然显著，尤其是铁蛋白，即使在控制腰围后仍然存在。铁蛋白和 CRP 与人体测量学，葡萄糖相关测量值和肝酶相关，但 WBC 仅与女性的甘油三酯相关。
（1）根据铁蛋白谱，男性表现出更严重的炎症，并且肝脏失调的迹象也更多；（2）所有差异在调整 BMI 差异后仍然存在，铁蛋白在控制腰围后仍然具有统计学意义；（3）在两性中，炎症标志物通常与不同的人体测量学，肝酶和葡萄糖稳态标志物相关；（4）炎症和生化性别差异可能对心血管风险和其他合并症有预后意义，值得进一步研究。
