Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
J Surg Oncol. 2010 Apr 1;101(5):413-7. doi: 10.1002/jso.21499.
The purpose of the present study was to identify prognostic factors and patterns of recurrence in patients with stage IB-IIB cervical adenocarcinoma who had undergone radical surgery and to compare these patterns with those observed in squamous cell carcinoma (SCC) patients.
We retrospectively reviewed 303 patients (97 with adenocarcinoma and 206 with SCC) with stage IB-IIB cervical cancer who had undergone radical hysterectomy and pelvic lymphadenectomy.
In the case of the adenocarcinoma patients, lymph node metastasis and parametrial invasion were independent indicators of disease-free survival, whereas lymph node metastasis was the only independent prognostic factor for the overall survival of the patients. The sites of recurrence did not significantly differ between the adenocarcinoma and SCC patients. In parametrium-positive patients, adenocarcinoma was found to be an independent prognostic factor for disease-free survival. In patients with positive pelvic lymph node, adenocarcinoma was found to be an independent prognostic factor for both disease-free and overall survival.
Adenocarcinoma was found to be an independent prognostic factor for survival in patients with positive pelvic node or parametrial extension. Furthermore, the patterns of recurrence did not differ significantly between the adenocarcinoma and SCC patients.
本研究旨在识别接受根治性手术的 IB-IIB 期宫颈腺癌患者的预后因素和复发模式，并将这些模式与观察到的鳞癌（SCC）患者进行比较。
我们回顾性分析了 303 例接受根治性子宫切除术和盆腔淋巴结切除术的 IB-IIB 期宫颈癌患者（97 例腺癌和 206 例 SCC）。
在腺癌患者中，淋巴结转移和宫旁侵犯是无病生存的独立指标，而淋巴结转移是患者总生存的唯一独立预后因素。腺癌和 SCC 患者的复发部位无显著差异。在宫旁阳性患者中，腺癌是无病生存的独立预后因素。在盆腔淋巴结阳性的患者中，腺癌是无病和总生存的独立预后因素。
在盆腔淋巴结阳性或宫旁侵犯的患者中，腺癌是生存的独立预后因素。此外，腺癌和 SCC 患者的复发模式无显著差异。
