Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.
J Biomed Mater Res B Appl Biomater. 2010 May;93(2):436-41. doi: 10.1002/jbm.b.31600.
By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste. As the paste does not contain water, no setting reaction starts and thus the working time is indefinite. Powder/liquid ratios (P/L) of 2.25, 3.5 and 4.75 were evaluated. Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction. The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST. Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa. The microstructure mainly consisted of monetite, 1-5 microm in grain size. After 4 weeks in PBS, the strength increased. As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements. Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties.
通过使用预先混合的磷酸钙水泥（CPC），可以极大地改善水泥的处理性能，这对于传统的可注射 CPC 来说是一个挑战。以前的预混水泥是基于磷灰石水泥的。本文开发并评估了酸性水泥。一水合单磷酸钙和β-磷酸三钙与甘油混合形成糊状物。由于糊状物不含水，因此不会开始凝固反应，因此工作时间是无限的。评估了粉末/液体比（P/L）为 2.25、3.5 和 4.75。在磷酸盐缓冲盐水（PBS）溶液中放置 1 天、1 周和 4 周后，测量了凝固时间（ST）和抗压强度（CS），并使用电子显微镜和 X 射线衍射评估了相应的微观结构。当水泥置于 PBS 中时，ST 开始，范围从 28 到 75 分钟，较高的 P/L 会降低 ST。较高的 P/L 还会产生较高的 CS，范围从 2 到 16 MPa。微观结构主要由 1-5 微米大小的单水磷酸钙组成。在 PBS 中放置 4 周后，强度增加。由于酸性水泥在体内的吸收速度更快，因此这种水泥应该比磷灰石水泥能更快地促进骨再生。与普通 CPC 相比，预先混合的水泥具有很大的处理优势，并且可以用相似的 ST 和机械性能来配制。
