Sheikh Zeeshan, Najeeb Shariq, Khurshid Zohaib, Verma Vivek, Rashid Haroon, Glogauer Michael
Faculty of Dentistry, Matrix Dynamics Group, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada.
School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TN, UK.
Materials (Basel). 2015 Aug 31;8(9):5744-5794. doi: 10.3390/ma8095273.
This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.
本综述讨论并总结了用于骨修复的可生物降解材料的最新进展。在骨科和颌面应用中，选择使用可降解和不可降解装置时必须仔细权衡。传统的用于骨合成的可生物降解装置在低负荷或轻度承重应用中已取得成功。然而，材料科学领域的持续研究和最新进展已促成具有更高强度和机械性能的生物材料的开发。为此，包括聚合物、陶瓷和镁合金在内的可生物降解材料在骨修复和应用方面备受关注。下一代可生物降解材料将受益于最近在细胞与材料相互作用方面获得的知识，从而能更好地控制材料与周围骨组织之间的界面。用于骨修复和再生应用的下一代可生物降解材料需要更好地控制材料与周围骨组织之间的界面。此外，这些材料的机械性能以及降解/吸收特性需要进一步改进，以扩大其应用范围并取得更好的临床效果。
