Department of Materials Science and Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
J Biomed Mater Res A. 2010 Jul;94(1):137-45. doi: 10.1002/jbm.a.32673.
Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this study, N-methyl pyrrolidone was used as an approved solvent for parenteral pharmaceutical products especially implants with acceptable toxicological profile. A combined freeze drying and solvent casting methods were adopted for complete removal of the solvent from final scaffold structure. Biodegradable scaffolds based on poly (D,L-lactide-co-glycolide) and different percentages of nanohydroxyapatite (25, 35, and, 45% w/w) were characterized thoroughly regarding porosity, pore distribution as well as their bioactivity and biocompatibility. The results showed 70-80% porosity with a size distribution in the range of 50-200 mum for different conditions. Bioactivity of the scaffolds was directly dependent on the bioceramic content in the samples according to the results. Composites and neat samples showed the same cytocompatibility profile. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.
基于聚合物/生物陶瓷复合材料的支架制造的常规方法通常采用溶液浇铸然后进行颗粒溶出。在这种技术中，常见有机溶剂的残留物可能会被捕获，因此对最终支架的安全性存在担忧。在这项研究中，N-甲基吡咯烷酮被用作批准的溶剂，用于可注射药物产品，特别是具有可接受毒理学特性的植入物。采用冷冻干燥和溶剂浇铸相结合的方法，从最终支架结构中完全去除溶剂。基于聚（D，L-丙交酯-共-乙交酯）和不同百分比纳米羟基磷灰石（25、35 和 45wt%）的可生物降解支架在孔隙率、孔径分布以及生物活性和生物相容性方面进行了全面的表征。结果表明，不同条件下的孔隙率为 70-80%，孔径分布范围为 50-200 微米。根据结果，支架的生物活性直接取决于样品中的生物陶瓷含量。复合材料和纯样品显示出相同的细胞相容性。（c）2010 年 Wiley 期刊，生物医学材料研究，2010。
