Lü Ping, Hong Suling
Department of Otorhinolaryngology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(20):939-41.
To investigate the expression and distribution of aquaporin 5 (AQP5) in allergic rhinitis (AR) treated by fluticasone propionate and levocabastine.
Forty Wistar rats were divided randomly into AR (n=30) and control groups (n=10). After AR models were established, the AR rats were divided evenly into F group, L group and AR control group. Three groups were treated respectively for 28 days, then the expression of AQP5 in nasal mucous membrane were detected by immunohistochemistry assay.
The distribution of AQP5 was consistent in all groups. The expression of AQP5 in F group was significantly different from L group and AR group (P<0.05), while there was no significant difference between that of AR group and L group (P>0.05). The expression of AQP5 in L group was significantly different from that in control group (P<0.05).
High expressions of AQP5 in rat with AR indicated the positive correlation between AQP5 and AR. AQP5 might be one of pathological factors of AR concerned with glands excessive secretion and tissue edema. Glucocorticoid can down-regulate the expression of AQP5, but H1-receptor antagonist can not reduce the expression of AQP5.
探讨丙酸氟替卡松和左卡巴斯汀治疗变应性鼻炎（AR）时水通道蛋白5（AQP5）的表达及分布情况。
将40只Wistar大鼠随机分为AR组（n = 30）和对照组（n = 10）。建立AR模型后，将AR大鼠平均分为F组、L组和AR对照组。三组分别治疗28天，然后采用免疫组织化学法检测鼻黏膜中AQP5的表达。
各组AQP5的分布一致。F组AQP5的表达与L组和AR组相比差异有统计学意义（P < 0.05），而AR组与L组之间差异无统计学意义（P > 0.05）。L组AQP5的表达与对照组相比差异有统计学意义（P < 0.05）。
AR大鼠中AQP5的高表达表明AQP5与AR呈正相关。AQP5可能是与腺体过度分泌和组织水肿有关的AR病理因素之一。糖皮质激素可下调AQP5的表达，但H1受体拮抗剂不能降低AQP5的表达。
