Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Int J Neurosci. 2010 Jan;120(1):71-5. doi: 10.3109/00207450903428970.
Anti-aquaporin-4 (Aqp-4) antibody and complement system have emerged as major pathogenic factors in neuromyelitis optica (NMO). To test the significance of interleukin-6 (IL-6), another important humoral immunity factor, in NMO pathogenesis, we measured serum and cerebrospinal fluid (CSF) IL-6 levels of 23 NMO, 11 transverse myelitis, 16 optic neuritis, 27 relapsing remitting multiple sclerosis patients, and 20 neurologically normal controls. NMO and transverse myelitis patients had higher serum and CSF IL-6 levels than other groups. Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients. Our results suggest that IL-6 is involved in NMO pathogenesis presumably via anti-Aqp-4 associated mechanisms.
抗水通道蛋白 4（AQP-4）抗体和补体系统已成为视神经脊髓炎（NMO）的主要致病因素。为了测试白细胞介素 6（IL-6）作为另一个重要的体液免疫因子在 NMO 发病机制中的意义，我们测量了 23 例 NMO、11 例横贯性脊髓炎、16 例视神经炎、27 例复发缓解型多发性硬化症患者和 20 名神经正常对照者的血清和脑脊液（CSF）IL-6 水平。NMO 和横贯性脊髓炎患者的血清和 CSF IL-6 水平高于其他组。特别是，抗 AQP-4 阳性 NMO 患者（n=12）的血清/CSF IL-6 水平高于抗 AQP-4 阴性患者（n=11），并且 CSF IL-6 水平与 NMO 患者的抗 AQP-4 水平和疾病严重程度相关。我们的结果表明，IL-6 可能通过与抗 AQP-4 相关的机制参与 NMO 的发病机制。
