Exotic and Emerging Avian Viral Diseases Research Unit, Agricultural Research Service, US Department of Agriculture, Athens, Georgia 30605 USA.
Virol J. 2010 Feb 3;7:27. doi: 10.1186/1743-422X-7-27.
The current pandemic influenza A H1N1 2009 (pH1N1) was first recognized in humans with acute respiratory diseases in April 2009 in Mexico, in swine in Canada in June, 2009 with respiratory disease, and in turkeys in Chile in June 2009 with a severe drop in egg production. Several experimental studies attempted to reproduce the disease in turkeys, but failed to produce respiratory infection in turkeys using standard inoculation routes. We demonstrated that pH1N1 virus can infect the reproductive tract of turkey hens after experimental intrauterine inoculation, causing decreased egg production. This route of exposure is realistic in modern turkey production because turkey hens are handled once a week for intrauterine insemination in order to produce fertile eggs. This understanding of virus exposure provides an improved understanding of the pathogenesis of the disease and can improve poultry husbandry to prevent disease outbreaks.
当前的甲型 H1N1 流感（pH1N1）于 2009 年 4 月在墨西哥首次被发现，当时人类出现急性呼吸道疾病；2009 年 6 月在加拿大的猪群中出现呼吸道疾病；2009 年 6 月在智利的火鸡群中出现产蛋量严重下降的情况。一些实验研究试图在火鸡中重现这种疾病，但使用标准接种途径未能在火鸡中引起呼吸道感染。我们证明，pH1N1 病毒可以在实验性宫内接种后感染火鸡的生殖道，导致产蛋量下降。这种暴露途径在现代火鸡生产中是现实的，因为每周都要对火鸡母鸡进行一次宫内授精处理，以生产出可育的鸡蛋。对病毒暴露途径的了解，提高了对疾病发病机制的认识，并能改进家禽饲养以预防疾病爆发。
