Geneton Inc., Cabanova 14, Bratislava, Slovakia.
Med Hypotheses. 2010 Jun;74(6):1030-2. doi: 10.1016/j.mehy.2010.01.003. Epub 2010 Feb 2.
Although preeclampsia represents a major threat for many pregnant women, the pathogenesis of this complication is far from being clear. Recent studies suggest that preeclampsia is an autoimmune disorder. Auto-antibodies against angiotensin receptor might explain some of the pathologic findings associated with preeclampsia. However, the origin of the autoimmune reaction is unknown. Here we hypothesize that circulating fetal RNA in maternal plasma might transfect maternal cells. Expression of fetal specific sequences could lead to an immune reaction breaking the immune tolerance against some antigens. Male fetus bearing pregnancies could be at higher risk of preeclampsia due to expression of Y-specific transcripts. This hypothesis is testable by analyzing antibodies and T-lymphocytes of pregnant women with male and female fetuses.
虽然子痫前期对许多孕妇构成重大威胁，但这种并发症的发病机制远未明确。最近的研究表明，子痫前期是一种自身免疫性疾病。针对血管紧张素受体的自身抗体可能可以解释一些与子痫前期相关的病理发现。然而，自身免疫反应的起源尚不清楚。在这里，我们假设循环于母体外周血中的胎儿 RNA 可能转染母体细胞。胎儿特异性序列的表达可能导致免疫反应，破坏对某些抗原的免疫耐受。怀有男性胎儿的孕妇由于表达 Y 染色体特异性转录本，可能面临更高的子痫前期风险。这一假说可以通过分析怀有男性和女性胎儿的孕妇的抗体和 T 淋巴细胞来验证。
