Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak Michigan and Oakland University, Rochester, MI, USA. jimmy.espinoza@beaumont
Am J Obstet Gynecol. 2011 Nov;205(5):485.e24-7. doi: 10.1016/j.ajog.2011.06.034. Epub 2011 Jun 15.
Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear. This study compares the fetal plasma concentrations of adenosine from normal pregnancies with those from preeclampsia.
This secondary data analysis included normal pregnancies (n = 27) and patients with preeclampsia (n = 39). Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV).
Fetal plasma concentrations of adenosine were significantly higher in patients with preeclampsia (1.35 ± 0.09 μmol/L) than in normal pregnancies (0.52 ± 0.06 μmol/L; P < .0001). Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 ± 0.15 μmol/L), but not with normal UADV (0.58 ± 0.14 μmol/L), were significantly higher than in normal pregnancies (P < .0001).
Patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine.
临床观察表明胎儿在子痫前期的母体表现中起作用，但可能的信号机制仍不清楚。本研究比较了正常妊娠和子痫前期胎儿血浆中腺苷的浓度。
本二次数据分析包括正常妊娠（n = 27）和子痫前期患者（n = 39）。子痫前期患者分为子宫动脉多普勒血流速度异常（n = 25）和正常（n = 14）两组。
子痫前期患者胎儿血浆腺苷浓度明显高于正常妊娠（1.35 ± 0.09 μmol/L 比 0.52 ± 0.06 μmol/L；P <.0001）。子宫动脉多普勒血流速度异常的子痫前期患者胎儿血浆腺苷浓度（1.78 ± 0.15 μmol/L）明显高于正常妊娠（0.58 ± 0.14 μmol/L；P <.0001），但子宫动脉多普勒血流速度正常的子痫前期患者胎儿血浆腺苷浓度（0.58 ± 0.14 μmol/L）与正常妊娠无差异。
超声显示慢性胎盘-子宫缺血的子痫前期患者胎儿血浆腺苷浓度升高。
