Department of Biochemistry, Istanbul University, Turkey.
Cytokine. 2010 Apr;50(1):15-8. doi: 10.1016/j.cyto.2009.12.015. Epub 2010 Feb 2.
Inflammation is involved in development and progression of atherosclerosis. Interleukin-2 (IL-2) and interleukin-6 (IL-6) have been correlated with various cardiovascular diseases. Hyperhomocysteinemia is an important risk factor for atherosclerosis and thrombotic disease. Recent studies have demonstrated that homocysteine (Hcy) enhances productions of several pro-inflammatory cytokines. In the light of these findings, we decided to determine if any relationship exists between IL-2 and IL-6, the pro-inflammatory cytokines, and total homocysteine (tHcy) in acute coronary syndrome (ACS). A total of 102 patients with ACS and 90 healthy subjects were included in the study. The levels of tHcy, IL-2 and IL-6 were higher and folic acid was lower in patients as compared with those of controls. Furthermore, data of the area under ROC plot for IL-2 demonstrated that IL-2 had higher sensitivity. These data suggest that enhanced inflammation may be associated with tHcy-related cardiovascular disease.
炎症参与动脉粥样硬化的发生和发展。白细胞介素-2（IL-2）和白细胞介素-6（IL-6）与各种心血管疾病相关。高同型半胱氨酸血症是动脉粥样硬化和血栓性疾病的一个重要危险因素。最近的研究表明，同型半胱氨酸（Hcy）可增强几种促炎细胞因子的产生。鉴于这些发现，我们决定确定在急性冠状动脉综合征（ACS）中，促炎细胞因子白细胞介素-2（IL-2）和白细胞介素-6（IL-6）与总同型半胱氨酸（tHcy）之间是否存在任何关系。共有 102 例 ACS 患者和 90 例健康受试者纳入本研究。与对照组相比，ACS 患者的 tHcy、IL-2 和 IL-6 水平较高，叶酸水平较低。此外，ROC 曲线下面积的数据表明 IL-2 具有更高的敏感性。这些数据表明，增强的炎症可能与 tHcy 相关的心血管疾病有关。
