Department of Psychology, Texas A&M University, College Station, TX 77843, USA.
J Psychopharmacol. 2010 Jan;24(1):51-5. doi: 10.1177/0269881108092119.
Behavioural studies have yielded results that show lobeline has the ability to attenuate d-methamphetamine self-administration. Further in vivo and in vitro studies have demonstrated a blockade of mu-opioid receptors with lobeline. The present investigation examined the ability of lobeline to attenuate heroin intravenous (i.v.) self-administration when administered prior to testing. Male Sprague-Dawley rats were surgically implanted with jugular catheters and trained to lever press for i.v. heroin infusions (18 microg/kg) under a fixed ratio-2 schedule wherein two active lever presses resulted in heroin delivery. Rats then were tested for heroin self-administration after pretreatment with subcutaneous lobeline injections (0.3, 1.0, or 3.0 mg/kg, 15 min prior to testing sessions). At doses of 1.0 and 3.0 mg/kg, lobeline attenuated self-administration of heroin. The results suggest a potential for lobeline to be used in pharmacotherapy for opioid abuse.
行为研究的结果表明，洛贝林具有减弱 D-甲基苯丙胺自我给药的能力。进一步的体内和体外研究表明，洛贝林可以阻断μ-阿片受体。本研究探讨了洛贝林在测试前给药时减弱海洛因静脉（i.v.）自我给药的能力。雄性 Sprague-Dawley 大鼠接受颈静脉导管植入手术，并接受训练，以在固定比率-2 方案下按压杠杆以进行 i.v.海洛因输注（18 微克/千克），其中两次主动按压杠杆会导致海洛因输送。然后，在皮下给予洛贝林注射（0.3、1.0 或 3.0 毫克/千克，在测试前 15 分钟）后，对大鼠进行海洛因自我给药测试。在 1.0 和 3.0 毫克/千克的剂量下，洛贝林减弱了海洛因的自我给药。结果表明，洛贝林有可能用于阿片类药物滥用的药物治疗。
