Department of Radiology, Kobe University Graduate school of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Eur J Nucl Med Mol Imaging. 2012 May;39(5):840-5. doi: 10.1007/s00259-011-2057-9. Epub 2012 Feb 17.
To determine if the preoperative maximum standardized uptake value (SUVmax) measured by [(18)F]FDG PET/CT has prognostic value in patients with endometrial cancer.
A total of 57 patients with FIGO stage I-IV endometrial cancer underwent FDG PET/CT imaging before radical surgery. SUVmax of the primary tumour was compared with histological prognostic factors, and the relationship between SUVmax and recurrence was examined.
The median duration of follow-up was 33.1 months (range 4 to 68 months). SUVmax was significantly higher in patients with a higher FIGO stage (p = 0.0015), higher tumour histological grade (p < 0.0001), myometrial invasion (p = 0.0020), larger tumour size (p = 0.0056) and lymph node metastasis (p = 0.027). Univariate analysis showed that SUVmax (uncategorized value), FIGO stage, tumour histological grade, lymph node metastasis and lymphovascular space invasion were significantly associated with recurrence. However, multivariate analysis showed that only SUVmax (p = 0.045, hazard ratio 1.11, 95% CI 1.0028-1.231) was significantly associated with recurrence. Based on ROC curve analysis and log-rank tests, patients with a high a SUVmax (≥ 12.7) had a significantly lower disease-free survival rate than those with a low SUVmax (<12.7; p = 0.00042).
Preoperative FDG uptake by the primary tumour is significantly associated with recurrence in patients with endometrial cancer.
确定（18）F-FDG PET/CT 检测的术前最大标准化摄取值（SUVmax）在子宫内膜癌患者中的预后价值。
共有 57 例FIGO Ⅰ-Ⅳ期子宫内膜癌患者在根治性手术前接受了 FDG PET/CT 成像。比较了原发肿瘤 SUVmax 与组织学预后因素的关系，并研究了 SUVmax 与复发的关系。
中位随访时间为 33.1 个月（4-68 个月）。FIGO 分期较高（p = 0.0015）、肿瘤组织学分级较高（p < 0.0001）、肌层浸润（p = 0.0020）、肿瘤较大（p = 0.0056）和淋巴结转移（p = 0.027）的患者 SUVmax 更高。单因素分析显示，SUVmax（未分类值）、FIGO 分期、肿瘤组织学分级、淋巴结转移和脉管侵犯与复发显著相关。然而，多因素分析显示，只有 SUVmax（p = 0.045，危险比 1.11，95%CI 1.0028-1.231）与复发显著相关。基于 ROC 曲线分析和对数秩检验，SUVmax 较高（≥12.7）的患者无疾病生存率明显低于 SUVmax 较低（<12.7；p = 0.00042）的患者。
原发肿瘤的 FDG 摄取与子宫内膜癌患者的复发显著相关。
