Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8807, USA.
Cancer Metastasis Rev. 2010 Mar;29(1):109-22. doi: 10.1007/s10555-010-9204-9.
Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.
在过去的十年中，研究揭示了病理疾病状态下由 microRNAs 介导的新型调控机制，并激发了研究人员开始阐明 microRNAs 在调控癌症发生和发展相关基因中的具体作用。最近，microRNAs 已被探索作为癌症的治疗靶点和诊断标志物。本文综述了肿瘤发生中涉及 microRNAs 的研究进展，重点讨论了已证实对肺癌发生具有关键作用的基因的 microRNA 调控。我们讨论了在恶性转化、血管生成和肿瘤转移过程中发挥关键作用的基因的 microRNA 调控、癌症发生中 microRNA 表达失调以及基于 microRNA 的诊断和治疗的发展。
