Wang Yang, Zhang Xinwei, Liu Liang, Li Hui, Yu Jinpu, Wang Changli, Ren Xiubao
1 Department of Immunology, Tianjin Medical University Cancer Institute and Hospital , Tianjin, China .
Cancer Biother Radiopharm. 2013 May;28(4):261-7. doi: 10.1089/cbr.2012.1401. Epub 2013 Mar 15.
MicroRNAs (miRNAs) are a class of endogenous small noncoding regulatory RNAs, which are new regulators of gene expression. They interfere with multiple biological processes involved in tumorigenesis such as cell proliferation, cell cycle, apoptosis, angiogenesis, invasion, and metastasis. A large body of evidence shows that the aberrant expression of miRNAs in cancer patients provides numerous underlying merits as diagnostic, clinical pathological, prognostic markers, and as promising therapeutic targets of lung cancer, providing an insight into the clinical application for lung cancer. Here, we focus on specific miRNAs as biomarkers in lung cancer and briefly introduce the biological function and modification of miRNAs.
微小RNA（miRNA）是一类内源性小非编码调节RNA，是基因表达的新型调节因子。它们干扰肿瘤发生过程中涉及的多种生物学过程，如细胞增殖、细胞周期、凋亡、血管生成、侵袭和转移。大量证据表明，癌症患者中miRNA的异常表达作为诊断、临床病理、预后标志物以及作为肺癌有前景的治疗靶点具有诸多潜在优势，为肺癌的临床应用提供了见解。在此，我们聚焦于特定miRNA作为肺癌的生物标志物，并简要介绍miRNA的生物学功能和修饰。
