Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Eur J Appl Physiol. 2010 Jun;109(3):397-404. doi: 10.1007/s00421-010-1362-5. Epub 2010 Feb 4.
Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI <30 kg/m(2)), 20 non-obese (BMI <30 kg/m(2)) and 20 obese (BMI >35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.
肥胖 2 型糖尿病患者的血浆游离脂肪酸（FFA）、炎症标志物和脂肪因子浓度升高。这些改变的血浆浓度是否与糖尿病状态或肥胖存在有关尚不清楚。在这项横断面观察性研究中，我们比较了肥胖和非肥胖 2 型糖尿病患者与健康、非肥胖对照者的基础血浆 FFA、炎症标志物和脂肪因子浓度。选择了 20 名健康、血糖正常的男性（BMI<30kg/m²）、20 名非肥胖者（BMI<30kg/m²）和 20 名肥胖者（BMI>35kg/m²）2 型糖尿病患者参与本研究。各组在年龄和习惯性体力活动水平上相匹配。评估了身体成分、血糖控制和运动能力。采集基础血样以确定血浆瘦素、脂联素、抵抗素、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、高敏 C 反应蛋白（hsCRP）和 FFA 浓度。非肥胖型糖尿病患者和健康、血糖正常的对照组之间，血浆 FFA、炎症标志物（hsCRP、IL-6、TNF-α）、脂肪因子（脂联素、抵抗素、瘦素）和甘油三酯浓度无差异。与健康血糖正常的对照组相比，肥胖 2 型糖尿病患者的血浆 FFA、IL-6、hsCRP、瘦素和甘油三酯水平显著升高（P<0.05）。此外，肥胖患者与非肥胖糖尿病患者相比，血浆 hsCRP 和瘦素水平显著升高（P<0.05）。观察到血浆参数与血糖控制之间存在显著相关性，但在调整了躯干脂肪组织量后相关性消失。血浆瘦素、hsCRP、IL-6 和 FFA 浓度升高与肥胖有关，而与 2 型糖尿病状态不一定有关。
