Giandalia A, Alibrandi A, Giorgianni L, Lo Piano F, Consolo F, Longo Elia G, Asztalos B, Cucinotta D, Squadrito G, Russo G T
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Unit of Statistical and Mathematical Sciences, Department of Economics, University of Messina, Messina, Italy.
Diabetol Metab Syndr. 2021 Sep 8;13(1):98. doi: 10.1186/s13098-021-00715-7.
Obesity-associated coronary heart disease (CHD) risk is higher in women than in men with type 2 diabetes (T2DM). Resistin, an adipokine secreted by adispose tissue, may contribute to this higher risk.
To explore the relationships among resistin levels and common inflammatory and endothelial dysfunction markers and CHD risk in obese post-menopausal T2DM women.
Serum levels of resistin, hsCRP, IL-6, Soluble vascular cell adhesion molecule (sVCAM), homocysteine (tHcy), HOMA-IR and metabolic parameters were determined in a group of 132 T2DM women with and without documented CHD and in 55 non-diabetic women.
Resistin, sVCAM, IL-6 and tHcy levels were comparable in T2DM and controls. CHD women showed higher resistin, sVCAM and tHcy levels than those without CHD, and for resistin this difference remained significant after age-adjustment (P = 0.013); conversely hsCRP were ~ 2X higher in T2DM women than in controls (P = 0.0132) without any difference according to CHD history. At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independently associated to resistin levels at stepwise regression analysis. Resistin levels were independently associated to CHD, increasing the risk by 1.15 times (0.986-1.344 95% CI), together with age, tHcy, LDL-C and hypertension.
Circulating resistin levels were comparable in obese/overweight T2DM and control women. In T2DM women, resistin levels correlated with markers of renal function, systemic inflammation and endothelial dysfunction and were independently associated with a higher CHD risk.
在2型糖尿病（T2DM）患者中，肥胖相关的冠心病（CHD）风险在女性中高于男性。抵抗素是一种由脂肪组织分泌的脂肪因子，可能导致这种更高的风险。
探讨肥胖绝经后T2DM女性中抵抗素水平与常见炎症和内皮功能障碍标志物以及CHD风险之间的关系。
测定了132例有或无CHD记录的T2DM女性以及55例非糖尿病女性的血清抵抗素、高敏C反应蛋白（hsCRP）、白细胞介素-6（IL-6）、可溶性血管细胞粘附分子（sVCAM）、同型半胱氨酸（tHcy）、胰岛素抵抗指数（HOMA-IR）和代谢参数水平。
T2DM患者和对照组的抵抗素、sVCAM、IL-6和tHcy水平相当。CHD女性的抵抗素、sVCAM和tHcy水平高于无CHD的女性，且抵抗素在年龄调整后差异仍有统计学意义（P = 0.013）；相反，T2DM女性的hsCRP比对照组高约2倍（P = 0.0132），根据CHD病史无差异。单因素分析显示，抵抗素水平与年龄、腰围、高血压、tHcy、hsPCR、sVCAM、IL-6、高密度脂蛋白胆固醇、甘油三酯和肌酐水平显著相关，但逐步回归分析中只有肌酐、甘油三酯、hsCRP、IL-6和sVCAM与抵抗素水平独立相关。抵抗素水平与CHD独立相关，使风险增加1.15倍（95%CI：0.986 - 1.344），同时与年龄、tHcy、低密度脂蛋白胆固醇（LDL-C）和高血压相关。
肥胖/超重T2DM女性和对照女性的循环抵抗素水平相当。在T2DM女性中，抵抗素水平与肾功能、全身炎症和内皮功能障碍标志物相关，并与更高的CHD风险独立相关。
